I am 42yo and began trikafta 3 years ago while in the drug study. I felt amazing at first and bumped up my fev1 from 40's to 60's. I did notice side effects like insomnia and fatigue, but eventually after a year or so, I began having a weird, almost like a hangover sensation with all alcohol while actually drinking them. I can only explain it as a dull headache/brain fog. It has now progressed to all the time with only occasional days that it is not present. I cut out all alcohol, all refined sugars, and gmo's. I also switched to all organic meats/veggies/fruits and it has only gotten worse. I am now convinced it has to be the trikafta. I am wondering how many others may be experiencing this effect and what other s.e.'s have you had with it. I don't think it is worth the risk to come off of it and pray that there is another alternative available soon. I am just looking to find out how common this feeling is and if anyone has found anything that helps to improve this feeling?